Overexpression of β-Catenin Induces Cisplatin Resistance in Oral Squamous Cell Carcinoma

Figure 3

Overexpression of -catenin increased the chemoresistance of SCC-25 cells to cisplatin and promoted cell survival. (a) Overexpression of -catenin increased the expression levels of Bcl-2, MRP-1, and MDR-1 compared to the controls. (b) Western blot analysis of the protein expression levels of Bcl-2, MRP-1, and MDR-1. (c) Expression of -catenin was involved in the Wnt signaling pathway by regulation of GSK-3 and C-myc. (d) Western blot analysis of the protein expression levels of GSK-3 and C-myc. .

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