BioMed Research International / 2016 / Article / Tab 3 / Review Article
Application of PK/PD Modeling in Veterinary Field: Dose Optimization and Drug Resistance Prediction Table 3 Classification of antibacterial drugs according to pharmacokinetics and pharmacodynamics indices. Different group of antibacterials, their bacterial effect, and PK/PD integration most closely related to their clinical effect.
Group Drugs PK/PD indices Activity Bacterial effect Duration of PAE References 1 Aminoglycosides /MIC or AUC/MICPrimarily bactericidal Concentration-dependent Prolonged Martinez et al., 2014 [17 ] Fluoroquinolone AUC/MIC Bactericidal Concentration-dependent Prolonged Martinez et al., 2014 [17 ] Enrofloxacin /MIC/AUC : MICBacteriostatic bactericidal Concentration-dependent Balaje et al., 2013 [49 ] Azithromycin AUC24 /MIC Tetracycline AUC24 /MIC Bacteriostatic Time-dependent Prolonged Martinez et al., 2014 [17 ] Colistin AUC/MIC Concentration-dependent Short Hengzhuang et al., 2012 [59 ] Metronidazole /MIC/AUC : MIC Concentration-dependent Paul et al., 2005 [60 ] 2 Ketolides
% > MIC Bacteriostatic or bactericidal Time-dependent Prolonged Martinez et al., 2014 [17 ] Penicillins Carbapenems Cephalosporins % > MIC Bactericidal Time-dependent Non or brief against Gram-negative and prolonged against Gram-positive Martinez et al., 2014 [17 ] Lincosamides (clindamycin) % > MIC Bacteriostatic Time-dependent Brief Martinez et al., 2014 [17 ] Trimethoprim % > MIC Bacteriostatic alone and bactericidal with combination Time-dependent Brief Martinez et al., 2014 [17 ] Glycopeptides (vancomycin) % > MIC Bactericidal Time-dependent Prolonged Martinez et al., 2014 [17 ]