Quantitative In Vitro and In Vivo Evaluation of Intestinal and Blood-Brain Barrier Transport Kinetics of the Plant N-Alkylamide Pellitorine

Figure 3

Blood-to-brain transport (multiple time regression experiment) results of pellitorine in mice. The ratio of pellitorine concentration in brain versus serum (μL serum/g brain) is plotted versus the exposure time (min). Start and end point were performed in duplicate. The data were fitted using a biphasic model.