The Epithelial Sodium Channel and the Processes of Wound Healing

Figure 4

Possible signaling pathways involved in ENaC activation during wound healing. The scheme highlights possible effects of some signals triggered early in the healing process, that is, the calcium, H₂O₂, and ERK1/2 waves (cf. Figure 1). The dashed arrow indicates that the suggested calcium effect does not take place in some cell types. ATP binds to its plasma membrane receptor and determines an increase in cytosolic calcium. For the case of the P2Y₁₁ receptor, ATP binding also stimulates the adenylyl cyclase (AC).