A Long-Acting BMP-2 Release System Based on Poly(3-hydroxybutyrate) Nanoparticles Modified by Amphiphilic Phospholipid for Osteogenic Differentiation

Figure 1

The schematic of a long-acting BMP-2 release system based on poly(3-hydroxybutyrate) nanoparticles loaded with BMP-2 modified by amphiphilic phospholipid for osteogenic differentiation. BPC: BMP-2-phospholipid complex; In-BMP: free-BMP only within initial 2 days; Con-BMP: continuous free-BMP-2 within 20 days; B-PHB NPs: PHB nanoparticles loaded with pure BMP-2; B-PHB NPs: PHB nanoparticles loaded with pure BMP-2; BPC-PHB NPs: PHB nanoparticles loaded with BPC.