Efficacy of Linezolid and Fosfomycin in Catheter-Related Biofilm Infection Caused by Methicillin-Resistant Staphylococcus aureus

Figure 1

Time-kill curves of linezolid plus fosfomycin in vitro. 154311 MRSA strain was used in this assay. The concentrations of antimicrobial agents in each group were LIN, 1/2x MIC (1 mg/L) linezolid; FOS, 1/16x MIC (4 mg/L), 1/8x MIC (8 mg/L), 1/4x MIC (16 mg/L), and 1/2x MIC (32 mg/L) fosfomycin; LIN + FOS, 1/2x MIC (1 mg/L) linezolid plus 1/16x (4 mg/L), 1/8x (8 mg/L), 1/4x (16 mg/L), and 1/2x MIC (32 mg/L) fosfomycin; control: broth alone. Data are presented as mean ± SD. All experiments were repeated three times.