Efficacy of Linezolid and Fosfomycin in Catheter-Related Biofilm Infection Caused by Methicillin-Resistant Staphylococcus aureus
Table 2
Bacterial counts changes of the three biofilm kinds cultured by methicillin-resistant Staphylococcus aureus after 24 hours of exposure to three antibiotics alone or in combination with linezolid, compared to the viable bacterial counts in biofilm without antibiotic exposure.
Drugs
Bacterial counts (cfu/mL)
154311
152898
159228
Mean
SD
Mean
SD
Mean
SD
No antibiotics
6.50
0.17
6.89
0.02
7.16
0.13
LIN 1/8x MIC
6.48
0.12
6.88
0.03
6.71
0.22
FOS 1/8x MIC
6.07
0.12
6.26
0.13
7.23
0.23
LIN 1/8x MIC + FOS 1/8x MIC
5.64
0.09
6.14
0.33
6.75
0.50
LIN 1/4x MIC
6.24
0.13
6.74
0.02
6.44
0.10
FOS 1/4x MIC
5.14
0.09
6.15
0.15
7.13
0.12
LIN 1/4x MIC + FOS 1/4x MIC
4.09
0.22
5.97
0.10
6.96
0.06
LIN 1/2x MIC
5.74
0.14
6.39
0.05
6.20
0.09
FOS 1/2x MIC
4.87
0.08
6.28
0.06
6.75
0.30
LIN 1/2x MIC + FOS 1/2x MIC
1.86
0.10
5.30
0.09
6.40
0.07
LEV 1/8x MIC
6.49
0.17
6.58
0.10
6.79
0.27
LIN 1/8x MIC + LEV 1/8x MIC
6.20
0.24
7.12
0.17
7.20
0.26
LEV 1/4x MIC
6.14
0.06
6.53
0.15
7.19
0.23
LIN 1/4x MIC + LEV 1/4x MIC
5.34
0.08
6.50
0.11
6.87
0.27
LEV 1/2x MIC
6.38
0.17
6.43
0.26
7.23
0.23
LIN 1/2x MIC + LEV 1/2x MIC
5.35
0.12
6.56
0.12
6.42
0.09
RIF (1 mg/L)
6.04
0.37
6.70
0.07
6.67
0.34
LIN 1/8x MIC + RIF (1 mg/L)
6.30
0.14
6.78
0.09
6.84
0.25
LIN 1/4x MIC + RIF (1 mg/L)
5.36
0.28
6.71
0.05
6.86
0.11
LIN 1/2x MIC + RIF (1 mg/L)
5.50
0.16
6.48
0.24
6.47
0.32
LIN: linezolid; FOS: fosfomycin; LEV: levofloxacin; RIF: rifampin Data are shown as means ± standard deviations. An asterisk () indicates significant difference .
