WWOX CNV-67048 Functions as a Risk Factor for Epithelial Ovarian Cancer in Chinese Women by Negatively Interacting with Oral Contraceptive Use
Table 2
Associations between WWOX CNV-67048 copy numbers and EOC risk and stages.
CNV-67048 genotypes
(%)
(%)
Crude OR (95% CI)
Adjusted OR (95% CI)
Case-control study
Patients
Controls
Total number
549
571
2-copy
339 (61.75)
397 (69.53)
0.005
1.000 (ref.)
1.000 (ref.)
1-copy
181 (32.97)
160 (28.02)
1.325 (1.024–1.714)
1.268 (0.967–1.663)
0-copy
29 (5.28)
14 (2.45)
2.425 (1.261–4.665)
2.198 (1.111–4.348)
1 + 0-copy
210 (38.25)
174 (30.47)
1.413 (1.103–1.811)
1.346 (1.037–1.747)
Trend test value
0.002
0.009
Case only study
Stages III + IV
Stages I + II
Total number
506
43
0.308
2-copy
309 (61.07)
30 (69.77)
1.000 (ref.)
1.000 (ref.)
1-copy
168 (33.20)
13 (30.23)
1.255 (0.637–2.470)
1.330 (0.655–2.701)
0-copy
29 (5.73)
0 (0.00)
—
—
1 + 0-copy
197 (38.93)
13 (30.23)
1.471 (0.749–2.888)
1.554 (0.771–3.129)
Trend test value
0.129
0.112
Adjusted in a logistic regression model that included age, age at menarche, number of births, menstrual history, oral contraceptive use, family history of cancer, smoking status, and alcohol intake.
