WWOX CNV-67048 Functions as a Risk Factor for Epithelial Ovarian Cancer in Chinese Women by Negatively Interacting with Oral Contraceptive Use
Table 3
Associations between CNV-67048 and EOC risk stratified by selected variables.
EOC Patients ()
Controls ()
Adjusted OR (95% CI)
2-copy (%)
1 + 0-copy (%)
2-copy (%)
1 + 0-copy (%)
1 + 0-copy versus 2-copy
Age (years)
≤55
177 (63.90)
100 (36.10)
206 (67.99)
97 (32.01)
1.175 (0.817–1.692)
0.396
>55
162 (59.56)
110 (40.44)
191 (71.27)
77 (28.73)
1.474 (0.990–2.194)
Age at menarche (years)
<15
133 (63.03)
78 (36.97)
177 (68.87)
80 (31.13)
1.315 (0.878–1.971)
0.564
≥15
124 (67.76)
59 (32.24)
207 (70.65)
86 (29.35)
1.193 (0.775–1.839)
Number of births
0
10 (62.50)
6 (43.75)
7 (63.64)
4 (36.36)
0.414 (0.043–4.002)
0.075
1–3
238 (58.19)
171 (41.81)
342 (69.80)
148 (30.20)
1.556 (1.164–2.081)
≥4
91 (73.39)
33 (26.61)
48 (68.57)
22 (31.43)
0.873 (0.442–1.722)
Menstrual history
Premenopause
89 (58.55)
63 (41.45)
92 (70.23)
39 (29.77)
1.451 (0.788–2.671)
0.563
Menopause
250 (62.97)
147 (37.03)
305 (69.32)
135 (30.68)
1.262 (0.931–1.710)
Oral contraceptive use
Never
239 (57.73)
175 (42.27)
283 (70.93)
116 (29.07)
1.825 (1.348–2.471)
0.042
Seldom
35 (62.50)
21 (37.50)
51 (65.38)
27 (34.62)
1.019 (0.454–2.291)
Often
23 (69.70)
10 (30.30)
33 (67.35)
16 (32.65)
0.464 (0.110–1.953)
Family history of cancer
Yes
23 (57.50)
17 (42.50)
25 (65.79)
13 (34.21)
2.440 (0.826–7.208)
0.654
No
316 (62.08)
193 (37.92)
372 (69.79)
161 (30.21)
1.333 (1.016–1.748)
Smoking status
Ever
43 (63.24)
25 (36.76)
37 (68.52)
17 (31.48)
1.353 (0.513–3.573)
0.488
Never
296 (61.54)
185 (38.46)
360 (69.63)
157 (30.37)
1.528 (1.165–2.003)
Pack-years smoked
≥20
23 (63.89)
13 (36.11)
14 (77.78)
4 (22.22)
10.067 (1.110–91.293)
0.695
<20
20 (62.50)
12 (37.50)
23 (63.89)
13 (36.11)
0.676 (0.175–2.616)
0
296 (61.54)
185 (38.46)
360 (69.63)
157 (30.37)
1.528 (1.165–2.003)
Alcohol intake
Ever
24 (70.59)
10 (29.41)
36 (73.47)
13 (26.53)
1.548 (0.383–6.248)
0.455
Never
315 (61.17)
200 (38.83)
361 (69.16)
161 (30.84)
1.401 (1.070–1.835)
Adjusted in a logistic regression model that included age, age at menarche, number of births, menstrual history, oral contraceptive use, family history of cancer, smoking status, and alcohol intake. value from a multiple interaction analysis.
