Genetic Analysis of the Atrial Natriuretic Peptide Gene Polymorphisms among Essential Hypertensive Patients in Malaysia
Table 3
Genotypes and allele frequencies distribution of gene polymorphisms between two patient groups and control subjects.
Genotype and allele frequency
EHT
EHT+T2DM
Control
(%)
(%)
(%)
Insertion/deletion
II
57 (76)
71 (80.7)
133 (84.7)
ID
12 (16)
14 (15.9)
21 (13.4)
DD
6 (8)
3 (3.4)
3 (1.9)
I
126 (84)
156 (88.6)
287 (91.4)
D
12 (16)
20 (11.4)
27 (8.6)
value
0.027/0.015
0.219/0.200
—
Post hoc test
II vs ID
0.749
—
—
II vs DD
0.056
—
—
ID vs DD
0.195
—
—
Odds ratio (95% CI)
0.494 (0.274–0.890)
0.734 (0.399–0.890)
—
A191G
GG
54 (72)
69 (78.4)
124 (79)
GA
17 (22.7)
17 (19.3)
31 (19.7)
AA
4 (5.3)
2 (2.3)
2 (1.3)
G
125 (83.3)
155 (89.1)
279 (88.9)
A
25 (16.7)
19 (10.9)
35 (11.1)
value
0.761/0.067
0.451/0.534
—
Odds ratio (95% CI)
0.627 (0.360–1.093)
1.023 (0.566–1.850)
—
EHT refers to essential hypertensive patients, EHT + T2DM refers to essential hypertensive patients with Type 2 Diabetes Mellitus, and control refers to healthy subjects. value < 0.05.
