Inhibition of DNA Topoisomerase Type II<i>α</i> (TOP2A) by Mitoxantrone and Its Halogenated Derivatives: A Combined Density Functional and Molecular Docking Study

<div>Optimized structure of mitoxantrone (D) and its halogenated derivatives (D1, D2, D3, D4, D5, D6, D7, D8, D9, and D10) calculated at B3LYP/MidiX level of theory.</div>

BioMed Research International

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Figure 1: Inhibition of DNA Topoisomerase Type II<i>α</i> (TOP2A) by Mitoxantrone and Its Halogenated Derivatives: A Combined Density Functional and Molecular Docking Study 

Figure 1 | Inhibition of DNA Topoisomerase Type IIα (TOP2A) by Mitoxantrone and Its Halogenated Derivatives: A Combined Density Functional and Molecular Docking Study 