Bioartificial Therapy of Sepsis: Changes of Norepinephrine-Dosage in Patients and Influence on Dynamic and Cell Based Liver Tests during Extracorporeal Treatments
Table 2
Age, scores, and results of laboratory parameters, of hemodynamic monitoring (PiCCO-System), and of dynamic measurement of the liver function (LiMON-System) at inclusion or on day 1 (before granulocyte therapy) of survivors and nonsurvivors (median/0.25–0.75 quartile).
Survivors
Nonsurvivors
Statistical significance ()
Age (years)
59 (57–76)
67 (66–72)
n.s.
Surgery/no surgery
4/1
5/0
APACHE II at ICU arrival/at inclusion
20.5 (17.8–25)/22 (22–34)
27 (27–33)/30 (28–32)
n.s.
SOFA at inclusion
8 (6–10)
14 (13–14)
n.s.
SAPS II at inclusion
47 (44–62)
74 (73–78)
0.032
MODS at inclusion
8 (7–12)
12 (11–13)
n.s.
Bilirubin (µmol/L)
12 (11–17)
44 (30–145)
0.016
ALAT (U/L)
32 (20–45)
37 (30–219)
n.s.
ASAT (U/L)
62 (44–74)
105 (52–669)
n.s.
Ammonia (mmol/L)
36 (32–62)
39 (38–61)
n.s.
PCT (ng/mL)
7.3 (0.5–43)
10.4 (7.4–14.6)
n.s.
Leukocytes (GpT/L)
18.1 (14.8–18.1)
16.2 (13.9–22.2)
n.s.
Thrombocytes (GpT/L)
159 (89–278)
125 (47–269)
n.s.
Prothrombin time as INR
1.09 (1.01–1.1)
1.32 (1.11–1.33)
n.s.
Activated partial thromboplastin time (s)
36 (33–49)
48 (45–54)
n.s.
Creatinine (µmol/L)
143 (79–238)
178 (165–213)
n.s.
Urea (mmol/L)
15.7 (5.7–16)
14.7 (13.8–24.9)
n.s.
Lactate (mmol/L)
1.0 (0.9–1.8)
2.0 (1.6–2.1)
n.s.
Complement C3 (g/L)
1.1 (1.0–1.8)
0.7 (0.5–1.0)
n.s.
Complement C4 (g/L)
0.5 (0.4–0.9)
0.4 (0.2–0.5)
n.s.
HLA-DR/CD-14 positive cells (expression/cell)
6413 (5890–6970)
8980 (7640–9590)
n.s.
Cardiac index (L/m2/min)
3.5 (3.3–4.0)
2.5 (2.5–3.4)
n.s.
Stroke volume index (mL/m2)
48 (43–51)
29 (28–39)
n.s.
MAP (mmHg)
92 (84–93)
71 (69–85)
n.s.
Norepinephrine (µg/kg/min)
0.13 (0.06–0.21)
0.36 (0.29–0.51)
0.032
ICG-PDR on day 1 (%)/ICG-PDR/CI
14.4 (13.3–17.2)/5.6 (4.9–5.7)
5.3 (2.5–11.9)/2.9 (1.1–2.9)
0.048/0.05
ALAT: alanine aminotransferase. APACHE: Acute Physiology and Chronic Health Evaluation. ASAT: aspartate aminotransferase. CI: cardiac index. HLA: human leukocyte antigen. ICG-PDR: indocyanine green plasma disappearance rate. MAP: mean arterial pressure. MODS: multiorgan dysfunction syndrome (score). n.s.: not (statistically) significant. PCT: procalcitonin. SAPS: simplified acute physiology score. SOFA: sequential organ failure assessment (score).
