The Role of ^99mTc-Annexin V Apoptosis Scintigraphy in Visualizing Early Stage Glucocorticoid-Induced Femoral Head Osteonecrosis in the Rabbit

Figure 4

Serial ^99mTc-MDP bone scans in methylprednisolone treated rabbits. Animals from Figure 3 were scanned with ^99mTc-MDP, two days prior to ^99mTc-Annexin V imaging. (a) Abnormal ^99mTc-MDP is found by 8 weeks, as indicated by the arrow. (b) A significant increase in ^99mTc-MDP is observed only at 8 weeks after methylprednisolone exposure, at 8 weeks versus the rest of the time points. There were no significant differences in ^99mTc-MDP uptake between pretherapy (week 0) and 5 or 6 weeks.

(a)

(b)