Establishment of Simple and Routine Methods in Early Diagnosis of Gentamicin-Induced Kidney Injury Based on a Rat Model
Table 1
Serum levels of biomarkers in rats treated with different GM dosage and duration.
Items
Dosage (mg⋅kg−1)
Duration
Day 1
Day 3
Day 7
Day 14
TP (g⋅L−1)
0
83.430 ± 4.968
86.218 ± 1.918
87.352 ± 1.981
87.933 ± 0.443
4
75.944 ± 2.772
77.012 ± 2.534
75.588 ± 2.320
75.756 ± 0.054
20
73.333 ± 3.565
75.103 ± 2.558
72.604 ± 1.892
73.739 ± 2.828
100
70.749 ± 5.273
64.221 ± 2.961
63.169 ± 2.813
—
ALB (g⋅dL−1)
0
33.975 ± 2.602
39.374 ± 2.500
40.109 ± 2.729
41.122 ± 2.879
4
29.283 ± 2.405
28.406 ± 1.810
28.224 ± 1.937
30.250 ± 1.743
20
28.360 ± 2.866
26.942 ± 2.191
27.260 ± 1.852
28.346 ± 0.810
100
27.412 ± 2.767
24.628 ± 1.817
22.130 ± 2.143
—
CRE (mol⋅L−1)
0
179.056 ± 10.532
178.355 ± 16.177
170.954 ± 14.942
188.069 ± 7.859
4
204.523 ± 9.235
258.298 ± 10.460
258.892 ± 12.464
257.4305 ± 5.380
20
225.297 ± 15.217
285.645 ± 15.434
290.219 ± 11.497
288.910 ± 12.692
100
250.534 ± 23.519
331.240 ± 24.755
358.339 ± 30.563
—
BUN (mmol⋅L−1)
0
1.956 ± 0.335
1.125 ± 0.355
1.144 ± 0.252
1.665 ± 0.301
4
3.023 ± 0.256
4.085 ± 0.156
5.286 ± 0.659
6.168 ± 0.560
20
4.797 ± 0.675
6.399 ± 0.747
7.713 ± 0.356
8.176 ± 0.522
100
5.020 ± 0.380
7.063 ± 0.503
13.251 ± 0.399
—
UA (mol⋅L−1)
0
268.261 ± 15.242
267.636 ± 28.612
265.544 ± 16.261
275.924 ± 9.168
4
280.063 ± 30.455
283.889 ± 22.133
294.637 ± 13.512
320.956 ± 20.945
20
295.234 ± 29.676
291.494 ± 22.681
301.259 ± 18.651
329.063 ± 40.164
100
300.157 ± 34.472
306.532 ± 37.724
343.146 ± 37.630
—
Values are expressed as mean ± SD for five rats in each group. Groups: control (0 mg⋅kg−1) group, 4 mg⋅kg−1 GM group, 20 mg⋅kg−1 GM group, and 100 mg⋅kg−1 GM group. In each column, same letters indicate no significant difference (), with significant difference ().
