Research Article
Establishment of Simple and Routine Methods in Early Diagnosis of Gentamicin-Induced Kidney Injury Based on a Rat Model
Table 3
Change in urinary PRO in rats treated with different GM dosage and duration.
| | Dosage (mg⋅kg−1) | Duration | | Day 1 | Day 3 | Day 7 | Day 14 |
| | 0 | − | 33.33% | − | 57.14% | − | 71.43% | − | 67.14% | | +− | 66.67% | +− | 42.86% | +− | 28.57% | +− | 32.86% | | + | 0 | + | 0 | + | 0 | + | 0 | | 2+ | 0 | 2+ | 0 | 2+ | 0 | 2+ | 0 | | 3+ | 0 | 3+ | 0 | 3+ | 0 | 3+ | 0 |
| | 4 | − | 20.00% | − | 14.29% | − | 0 | − | 0 | | +− | 40.00% | +− | 14.29% | +− | 25.00% | +− | 40.00% | | + | 20.00% | + | 57.13% | + | 62.50% | + | 40.00% | | 2+ | 20.00% | 2+ | 14.29% | 2+ | 12.50% | 2+ | 20.00% | | 3+ | 0 | 3+ | 0 | 3+ | 0 | 3+ | 0 |
| | 20 | − | 14.29% | − | 12.50% | − | 0 | − | 0 | | +− | 42.85% | +− | 37.50% | +− | 28.57% | +− | 20.00% | | + | 28.57% | + | 25.25% | + | 42.86% | + | 20.00% | | 2+ | 14.29% | 2+ | 25.25% | 2+ | 28.57% | 2+ | 40.00% | | 3+ | 0 | 3+ | 0 | 3+ | 0 | 3+ | 20.00% |
| | 100 | − | 12.50% | − | 0 | − | 0 | − | | +− | 25.00% | +− | 14.29% | +− | 0 | | + | 37.50% | + | 42.85% | + | 16.67% | | 2+ | 25.00% | 2+ | 28.57% | 2+ | 33.33% | | 3+ | 0 | 3+ | 14.29% | 3+ | 50.00% |
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Groups: control (0 mg⋅kg−1) group, 4 mg⋅kg−1GM group, 20 mg⋅kg−1 GM group, and 100 mg⋅kg−1 GM group.
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