Research Article
Identification of Deleterious Mutations in Myostatin Gene of Rohu Carp (Labeo rohita) Using Modeling and Molecular Dynamic Simulation Approaches
Table 1
List of nsSNPs showing deleterious/nondeleterious scores as predicted by SIFT, PROVEAN, I-Mutant 2, and PANTHER.
| Amino acids change Protein position | subPSEC score | | Prediction by PANTHER-cSNP | PROVEAN score | PROVEAN prediction (cutoff = −2.5) | DDG value | I-Mutant stability prediction | SIFT score | Prediction |
| D76A | | 0.41009 | Deleterious | | Deleterious | | Decreased | 0.02 | Deleterious | Q204P | | 0.73838 | Tolerated | | Deleterious | | Decreased | 0.04 | Deleterious | C312Y | | 0.99982 | Deleterious | | Deleterious | | Increased | 0.06 | Tolerated | D313A | | 0.3933 | Tolerated | | Neutral | | Increased | 0.09 | Tolerated |
|
|