A Nested Case-Control Study of Association between Metabolome and Hypertension Risk
Table 2
Association of metabolites with incident hypertension.
Class
Metabolite
RT
Fold change
OR
Amino acids and derivatives
Threonine
21.87
0.12
1.46 × 10−4
0.33 (0.16–0.70)
1.78 × 10−4
Nicotinoyl glycine
8.28
0.49
2.31 × 10−2
0.52 (0.28–0.96)
1.21 × 10−2
Glycine
8.58
0.36
2.71 × 10−2
0.78 (0.44–1.38)
1.31 × 10−1
Phenylalanine
13.02
0.70
3.44 × 10−2
0.49 (0.26–0.91)
1.12 × 10−2
S-Carboxymethylcysteine
24.78
0.49
4.03 × 10−2
0.58 (0.32–1.05)
6.56 × 10−2
Tyrosine
16.70
0.58
4.76 × 10−2
0.73 (0.42–1.29)
3.79 × 10−1
Aspartic acid
21.22
0.55
4.92 × 10−2
0.53 (0.28–0.99)
2.38 × 10−2
Gly-Pro
13.38
0.40
4.99 × 10−2
0.71 (0.4–1.23)
1.02 × 10−2
Carbohydrate
Talose
16.88
10.88
1.69 × 10−6
11.64 (3.39–39.96)
9.01 × 10−5
Lyxose
14.47
2.29
1.24 × 10−4
2.88 (1.44–5.73)
4.26 × 10−5
Galactose
16.49
0.22
2.81 × 10−4
0.34 (0.17–0.7)
5.71 × 10−4
Glucose-1-phosphate
16.41
1.04 × 10−6
1.06 × 10−3
0.34 (0.16–0.71)
2.40 × 10−3
Methyl-beta-D-galactopyranoside
14.32
0.37
6.73 × 10−3
0.28 (0.13–0.6)
1.20 × 10−3
Dihydroxyacetone
7.06
0.50
3.12 × 10−2
0.62 (0.34–1.11)
9.84 × 10−2
Melezitose
23.25
0.48
3.81 × 10−2
0.54 (0.29–1.01)
8.38 × 10−2
Carboxylic acids and derivatives
Methylmalonic acid
8.13
3.04
1.47 × 10−7
5.24 (2.1–13.03)
2.37 × 10−5
Malonic acid
11.16
12.47
3.29 × 10−5
12.55 (3.4–46.39)
1.24 × 10−4
Shikimic acid
14.33
5.56
5.85 × 10−3
5.06 (2.07–12.33)
3.00 × 10−4
Oxalic acid
6.19
0.56
3.29 × 10−2
0.57 (0.31–1.02)
7.11 × 10−2
Phenols and derivatives
Thymol
14.17
0.31
4.14 × 10−3
0.43 (0.23–0.83)
6.00 × 10−3
Noradrenaline
8.45
0.49
7.05 × 10−3
0.46 (0.24–0.87)
5.49 × 10−3
2-Aminophenol
9.19
0.34
1.02 × 10−2
0.55 (0.29–1.01)
5.44 × 10−2
Others
2-Methoxyestrone
19.65
0.57
1.74 × 10−2
0.39 (0.2–0.76)
8.71 × 10−3
Alpha-tocopherol
27.36
0.60
3.23 × 10−2
0.47 (0.25–0.89)
3.82 × 10−2
Octadecanol
19.08
0.56
3.98 × 10−2
0.64 (0.36–1.14)
2.47 × 10−1
2-Aminoethanethiol
6.08
0.59
4.26 × 10−2
0.59 (0.32–1.06)
9.38 × 10−2
RT: retention time; fold change: ratio of metabolite levels between case and control groups; OR: odds ratio; : value adjusted for BMI, smoking, drinking, creatinine and C reactive protein, and postmenopausal status.
