Serum Heme Oxygenase-1 and BMP-7 Are Potential Biomarkers for Bone Metabolism in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis

Table 2

Correlation between HO-1, BMP-7, Runx2, and other biomarkers in patients with RA and AS. Correlations were performed using Spearman’s correlation coefficient ().

	RA ()			AS ()
	HO-1	BMP-7	Runx2	HO-1	BMP-7	Runx2
HO-1						−0.029
BMP-7						−0.131
Runx2				−0.029	−0.131
NMID	0.007	0.067		−0.023	−0.272
BALP	0.201	0.116	−0.115	−0.249	−0.319	0.097
CTX	0.247	0.209	−0.069	0.106	−0.255	0.328
TRAP-5b			0.134	−0.127		0.301

⁢; . RA: rheumatoid arthritis; AS: ankylosing spondylitis; HO-1: heme oxygenase-1; BMP-7: bone morphogenetic protein-7; Runx2: Runt related-transcription factor 2; NMID: N-terminal midfragment of osteocalcin; BALP: bone alkaline phosphatase; CTX: C-terminal telopeptide of type I collagen; TRAP-5b: tartrate-resistant acid phosphatase-5b.