Research Article
G2385R and I2020T Mutations Increase LRRK2 GTPase Activity
Table 1
The kinase activities of LRRK2 I2020T and G2385R mutants.
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+: assigned based on the graphic values of each mutant from the indicated studies. nt: not tested. All previous experiments cited here have used immunoprecipitates of cell lysate that was transiently transfected with full length LRRK2 except [24] which has used GST-LRRK2 [1326–2527] for transfection. The kinase activities have been detected by either [γ-] ATP or phospho-LRRK2 antibodies such as pS910 or pS935. The WT activity of each study was arbitrarily assigned as ++ and compared within each study, not between studies. |