Advantages and Limitations of Direct PCR Amplification of Bacterial 16S-rDNA from Resected Heart Tissue or Swabs Followed by Direct Sequencing for Diagnosing Infective Endocarditis: A Retrospective Analysis in the Routine Clinical Setting

Table 6

Calculation of sensitivity, specificity, and positive and negative predictive values. Calculation of sensitivity, specificity, and positive and negative predictive values is based on a dataset of . The gold standard is defined according to the criteria outlined in Definition of Diagnosed IE (Section 2).

		Diagnosis
PCR		30	3	90.9%	Positive predictive value
		60	10	14.3%	Negative predictive value
		33.3%	76.9%
		Sensitivity	Specificity