2-Methoxyestradiol Alleviates Experimental Autoimmune Uveitis by Inhibiting Lymphocytes Proliferation and T Cell Differentiation

Figure 2

Time-dependent 2ME2 effects on EAU mice. (a) Retina HE sections from 2ME2 and vehicle treated groups. Vehicle, scored 3. 2ME2 D0–D13, scored 0. 2ME2 D0–D6, scored 1.5. 2ME2 D7–D13, scored 2.5. (b) Disease score from 2ME2 D0–D13 group was the lowest among the four groups, followed by 2ME2 D0–D6 group and 2ME2 D7–D13 group and vehicle group scored the highest ( indicated a ), each group containing 5 mice.

(a)

(b)