Antiobesity and Antidiabetes Effects of a Cudrania tricuspidata Hydrophilic Extract Presenting PTP1B Inhibitory Potential

Figure 3

Effects of CTe on fat mass and insulin signaling in DIO mice. The HFD-fed mice were orally administered vehicle or CTe (20 or 100 mg/kg) for 3 weeks. At 28 h after the final CTe treatment, fat was collected from DIO mice. (a) Total fat weight. (b) Inguinal fat weight. (c) Epididymal fat weight. (d) p-IRS-1 and (e) p-Akt detection was estimated by Pathscan sandwich ELISA assay. Data are presented as the mean ± SD for each group (). Statistical significance was determined by Student’s t-test. and versus lean mice; , , and versus vehicle administered DIO mice.

(a)

(b)

(c)

(d)

(e)