Candidate SNP Markers of Chronopathologies Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters

Figure 1

Examples of the predictions by SNP_TATA_Comparator [35] for statistically significant alterations in the affinity of TATA-binding protein for human gene promoters. (a) The known biomedical SNP marker rs35036378 located within a promoter of the human ESR2 gene associated with a Mendelian disease. This SNP is now predicted (in this study) to be a candidate SNP marker of circadian comorbidities and complications of diseases that one can see in Table 1. (b) The candidate SNP marker rs4313857 identified in this study within the human CSNK1D gene (belongs to the circadian clock core), as shown in Table 2.

(a)

(b)