Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females

Table 6

Comparison of the genotype and allele frequencies of rs1799794 A>G in triple negative patients compared to the health control group.

	Triple negative cancer (total = 27)	Control (total = 145)	Breast cancer versus control			value
	Number (%)	Number (%)	OR	95% CI
XRCC3 rs1799794 A>G, genotype frequency
AA	7 (25.92)	93 (64.14)	Ref.
AG	16 (59.26)	28 (19.3)	0.949	0.35–2.58	0.01	0.91
GG	4 (14.81)	24 (16.55)	0.09	0.005–1.52	5.21	0.022
AG+GG	20 (74.07)	52 (35.86)	0.511	0.19–1.35	1.89	0.168
AA+AG	23 (85.19)	121 (83.44)	11.09	0.65–8.05	5.19	0.022
Alleles frequency
A	30 (55.55)	214 (73.74)	Ref.
G	24 (44.44)	76 (26.2)	0.35	0.15–0.855	5.7	0.016

OR = odds ratio; 95% CI = 95% confidence interval; = chi square. SNP = single nucleotide polymorphism.