Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females

Table 7

Association studies of rs1799794 (A/G), rs861539 (C/T), and rs1799796 (A/G) in XRCC3 in different types of cancer and in different populations.

Cancer types	Effect	Number	Population	Ref.
rs1799794 (A/G), association of G allele
Breast cancer	Protective	143	Saudis
Esophageal and gastric	Survival	258	Germans	[35]
Lung cancer	Decreased risk in carriers of G allele	—	Chinese	[33]
Breast cancer risk	Modified in patients carrying BRCA1, BRCA2 mutation	—	Belgian	[43]
Prostate cancer	Gastrointestinal toxicity	698	Spanish	[49]
Non-small-cell lung	Protective effect of G allele	507	Chinese	[34]
Breast cancer	No association		British	[2]
Ovarian cancer	Association	—	Meta-analysis	[44]
Breast cancer	Association	—	Jordanian	[37]
rs861539 (C/T), association of T allele
Breast cancer	No association	143	Saudis
Colorectal cancer	Increased risk (association)	100	Polish	[34]
Breast cancer	Increased risk (association)	1826	British	[2]
Bladder cancer	Protective role	214	Italian	[41]
Colorectal cancer	Protective role	128	British	[4]
Lung cancer	No association	272	Danish	[42]
Breast cancer	No association. Association with cancer progression and grading	700	Polish	[3]
Breast cancer	Association		Taiwanese	[38]
Breast cancer	No association		Jordanian	[37]
rs1799796 (A/G), association of G allele
Breast cancer	No association	143	Saudi
Bladder cancer	No association	696	American	[46]
Oral premalignant lesions	Strong association (increases risk)	147	American	[50]
Prostate cancer	No association	192	Indian	[48]
Urinary bladder cancer	No association	211	Indian	[30]
Breast cancer	Increases risk in BRCA1, BRCA2	—	Belgian	[43]
Breast cancer	Decreased risk	2205	British	[2]
Breast cancer	No association	1004	American	[47]
Lung cancer	No association	265	Danish	[42]
Ovarian cancer	No association	1600	British	[45]
Ovarian cancer	Association		Meta-analysis	[44]

= this study.