Research Article
Plasma Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Cardiovascular Events in Patients with Chronic Kidney Disease
Table 3
Predictors of cardiovascular events.
| Variable | Nonadjusted | Adjusted | HR (95% CI) | value | HR (95% CI) | value |
| Male (yes) | 0.99 (0.51–1.95) | 1.00 | | | Age (yes) | 1.04 (1.01–1.07) | 0.01 | 1.02 (0.99–1.05) | 0.24 | Diabetes (yes) | 1.87 (0.97–3.60) | 0.06 | | | Smoking (yes) | 0.84 (0.42–1.65) | 0.61 | | | Systolic BP (mmHg) | 1.02 (0.99–1.04) | 0.12 | | | BMI (kg/m2) | 0.95 (0.86–1.05) | 0.35 | | | Plasma NGAL (ng/mL) | 1.005 (1.003–1.007) | <0.0001 | 1.004 (1.002–1.006) | <0.0001 | Urinary NGAL (μg/gCr) | 1.00 (0.999–1.001) | 0.71 | | | BNP (pg/mL) | 1.005 (1.003–1.006) | <0.0001 | 1.005 (1.003–1.007) | <0.0001 | eGFR (mL/min/1.73 m2) | 0.96 (0.93–0.99) | 0.002 | 0.99 (0.96–1.04) | 0.87 | Hemoglobin (g/dL) | 0.72 (0.60–0.85) | <0.0001 | 0.94 (0.78–1.14) | 0.54 | hsCRP (mg/L) | 1.78 (1.32–2.35) | <0.0001 | 1.33 (0.98–1.82) | 0.07 | UACR (g/gCr) | 1.26 (1.09–1.44) | 0.001 | 1.16 (0.97–1.39) | 0.09 | Triglyceride (mg/dL) | 0.99 (0.99–1.00) | 0.36 | | | LDL-C (mg/dL) | 1.00 (0.99–1.01) | 0.40 | | | HDL-C (mg/dL) | 0.99 (0.97–1.00) | 0.21 | | | LVH of ECG | 1.75 (0.53–5.75) | 0.36 | | | ST-T change of ECG | 1.14 (0.35–3.76) | 0.83 | | | EF of UCG | 0.94 (0.88–1.00) | 0.056 | | | ARB or ACEi (yes) | 0.66 (0.33–1.30) | 0.23 | | | Statins (yes) | 0.96 (0.47–1.95) | 0.91 | | |
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; . Multivariate model includes all variables with by univariate analysis. ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; BMI, body mass index; BNP, B-type natriuretic peptide; BP, blood pressure; ECG, electrocardiogram; EF, ejection fraction; eGFR, estimated glomerular filtration rate; HDL-C, high-density lipoprotein-cholesterol; HR, hazard ratio; hsCRP, high-sensitivity C-reactive protein; LDL-C, low-density lipoprotein-cholesterol; LVH, left ventricular hypertrophy; NGAL, neutrophil gelatinase-associated lipocalin; UACR, urinary albumin creatinine ratio; UCG, ultracardiography.
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