Hypotensive Resuscitation among Trauma Patients

Table 2

In-hospital randomized controlled trials’ study criteria and outcomes.

Study	Study years	Inclusion criteria	Exclusion criteria	Study arms	Outcomes
Dutton et al. [9]	1996–1999	(i) Arrival at hospital directly from scene; (ii) Ongoing hemorrhage; (iii) SBP < 90 mmHg in first hour after injury	(i) Being pregnant; (ii) Central nervous system injury and altered consciousness or motor function; (iii) Being >55 years; (iv) History of diabetes or CAD	Conventional: received fluid to a target SBP > 100 mmHg; Low: received fluid to a target SBP of 70 mmHg	(i) No difference in in-hospital mortality (7.3% in each group)
Carrick et al. [11]	7/1/2007–3/28/2013	(i) Penetrating trauma; (ii) SBP ≤ 90 mmHg; (iii) Emergent laparotomy or thoracotomy to control bleeding	(i) Being pregnant; (ii) Blunt trauma; (iii) Being <14 years or >45 years; (iv) Known or suspected head injury; (v) Being incarcerated; (vi) Those with “opt-out” bracelet	HMAP: targeted intraoperative minimum MAP = 65 mmHg; LMAP: targeted intraoperative minimum MAP = 50 mmHg	(i) No differences in 30-day mortality (21.4% versus 26.3%) or 24-hour mortality (13% versus 20%) for LMAP and HMAP groups, respectively; (ii) No differences in acute MI, stroke, renal failure, hypotension, coagulopathy, thrombocytopenia, anemia, or infection between groups; (iii) Increased acute renal injury in the HMAP group (30% versus 13%)

Italicized outcomes are statistically significant, .
CAD: coronary artery disease; HMAP: high mean arterial pressure; ICU: intensive care unit; LMAP: low mean arterial pressure; MAP: mean arterial pressure; MI: myocardial infarction; SBP: systolic blood pressure.