Anaplasma marginale: Diversity, Virulence, and Vaccine Landscape through a Genomics Approach

Table 1

MSP1a tandem repeats reported worldwide. The wide genetic diversity observed is result, in most cases, of cattle movements, veterinary practices, and vector population dynamics.

Anaplasma marginale strain	Structure of msp1a tandem repeats									Ref.
Argentina
Virasoro		B	Q	B	C					[40]
Salta	B	B	M
Entre Ríos 1	F	M	M
Entre Ríos 2	F	M	M
Entre Ríos 3	F	M	M
Entre Ríos 4	F	M	M
Santa Fe 37		β	β	β
Santa Fe 43		β	β	β
Santa Fe 50		β	β	β
Santa Fe 59		β	β	β
Santa Fe 111	B	B	M
Santa Fe 473	B	B	M
Santa Fe 532	B	B	M
Santa Fe 116	B	B	M
Chaco 2 var1		22	13	18
Chaco 2 var2		β			β	β
Chaco 3 var1		22	13	18
Chaco 3 var2		11	10	10	11	10	15
Chaco 5		10	15
Chaco 7		22	13	18
Chaco 8		22	13	18
Córdoba 1	23	24	25	26	27	27
Córdoba 2	23	24	25	26	27	27
Quitilipi	28	29	m	29	M	F
Mercedes	23	30	31	31	31
Corrientes		β	β	β
Australia
Australia F12	8									[30]
Australia F72	8
Australia Darwin	8
Australia WA	8
Brazil
Minas-1		57	β	β						[33]
Minas-2	Is9	24	24	25	31
Minas-3		β	β
Minas-4	B	Q	B	M
Minas-5	13	27	27	27
Minas-6–10	72	62	61
Minas-11		57	13	18
Minas-12	72	62	61
Minas-13		β	β	13
Brazil	B	B	Q
Brazil 5	C	F	N
Brazil 9		β		M
Brazil 12		β	β	N
UFMG-1	13	42	13	18
UFMG-2	13	27	27
Paraná		β	β	β	β					[43]
Paraná 2	16	F	17	13	18
Paraná 3		10	15
Lins SP/7		10	15							[35]
Lins SP/10		10	15
Lins SP/16		10	15
Lins SP/11	191	13	18
Lins SP/12		β	β
Lins SP/110		β	β	β	13
Lins SP/703		β	β	192
Lins SP/1136		β	100
Lins SP/1228		β	β
Lins SP/1450	193	β	100
Lins SP/1453	191	13
Mambaí GO/1017B		β	β	β
Mambaí GO/1568B		β	β	β
Mambaí GO/1806B	E	F			F	F
AmRio1	162	F	17	F	F					[36]
AmRio2		β	β	β	F
Canada
Canadian bison	D	Q	Q	R						[30]
China
HB-A8	19	20	19	21						[30]
Cuba
Havana	A	B	B	B	B					[34]
Israel
Israel tailed 1FM3	1	F	M	3						[30]
Israel nontailed	1	4
Israel tailed 12M3	1	2	M	3
Azaria	1	F	M	3	3
Lhavot-Habasan	M	F	F	F
Or-Haner	M	F	F
Italy
Italy 6	Q	M	Q	Q	M					[30]
Italy 8	Q	N	N	N
Italy 30	M	M	M	Q
Italy 31	M	M	M	Q
Italy 32	5
Italy 47	6	7	7	7
Mexico
Mex-31-096-01	T	C	B	B	C	B				[32]
Mex-30-130-01	T	C	B	B	C	B	C
Mex-30-184-03	T	C	B	B	C	C
Mex-15-099-01		β	β
Mex-17-030-01		β	β
Mex-30-193-01		β	β
Mex-18-017-01		β	β
Mex-07-068-01		β	β		β
Mex-07-068-02		β	β		β
Tamaulipas 17, 18		β	β	β						[41]
Mex-07-065-01	β	β	β	β						[32]
Mex-30-184-02	73	β	β	β
Tamaulipas 15 (G9)		57	13	18						[41]
Mex-14-010-01		57	13	18						[32]
Mex-28-037-01		57	13	18
Mex-28-037-02	28	29	74	29	M	F
Mex-30-184-01	72	C	F
Mex-31-089-01	F	M	M
Mex-17-017-01	12	13	14
Mex-01-001-01	4	9	10	11	9
Tamaulipas 1 (G1)	56	57	58	59						[41]
Tamaulipas 13 (G2)	4	9	10	10	9
Tamaulipas 4 (G3)	60	61	61	62	61
Tamaulipas 7, 9, 10, 12 (G4)	4	63	63	27	12
Tamaulipas 11 (G5)	67	68	63	27	12
Tamaulipas 14 (G6)	69	61	70	71	61
Tamaulipas 5 (G7)	64	65	D	65	66
Tamaulipas 6, 8 (G8)	D	65	D	65	66
Philippines
Batangas	Ph1	β	β		β	β				[42]
	Me1	4	M	M	4	4	4
	Ph11	Ph11	Ph11	Ph11	M
	Ph1	27	27
	13	13
	13	27
	46	F
Cebu	13	13	14	14	13	14	14
	Ph4	17	Ph5	Ph6	Ph5	Ph7
	13	13	13	14	14
	Ph12	M	Ph12	M	M
	13	13	13	MGl10
	Ph9	Is1	Is1	Ph10
	13	14	14
	13	27	14
	13	27	27
	21	M	M
	46	Ph20	46
	13	27
	13	MGl10
	46	46
	46	F
	14
	17
	Me1
	Ph8
	13
Iloilo	Ph4	17	Ph5	Ph7	Ph5	Ph7
	Ph12	M	3	3	M
	Ph4	17	Ph5	Ph5	Ph7
	Me1	4	4	4
	Ph16	Ph17	MGl10
	Ph19	M	F
	13	27	13	14
Negros Occidental	Me1	4	M	M	4	4
	Ph21	62	61	62	61	62
	Me1	4	M	M	4
	Ph2	Is1	Is1	Is1
	Ph18	MGl10
	Ph3
	13	14
Negros Oriental	Ph4	17	Ph5	Ph7	Ph5	Ph7
	13	27
Puerto Rico
Puerto Rico	E									[30]
South Africa
SA12	34	13	4	37						[30]
SW82	34	13	4	37
SW62	34	13	4	37
SW162	34	13	4	37
SW134	34	13	4	37
SA66	34	13	4	37
SA193	34	4	37
SW32	34	13	13	37
SA14	34	F	4	H
SA10	33	35	35
SW29	3	3	38
SA71	3	3	38
SA302	3	3	38
SA196	3	3	38
SW114	3	13	4	4	37
SW109	27	4	13	13	37
SW44	27	4	4	4	37
SW90	27	13	4	13	4
SA239	27	4	13	4	4
SA183	27	13	4	44
SW34	34	45	45	46	37
SA191	27	37
SA189	27	37
SA4	27	18
SA63	39	37	13	13	13	13	37
SA240	40	Q	Q
SW113	41	13	13	13	4	37
SW112	42	43	25	31
SA243	3	36	3	36	36	3	36	38
LP-7	34	159								[37]
LP-10	27	13	3	36
LP-30	27	13	3
LP-34	34	13	3	38
LP-37	27	13	13	37
LP-46	3	38
LP-50	34	13	13
MP-C2	34	13	158	37
MP-C5	15	15	100	83
NW-C2	27	13	4	4	37
NW-C4	27	13	4	37
NW-C5	82	13	79	4	37
NW-CA-160312	34	13	3	36	38
NW-C4-160312	34	36	38	3
GP-C1	82	13	4	4	37
GP-C2	34	27	3	38	13	3	38
GP-C5	3	4	4	4	37
GP-C112105	34	37
GP-C4117105	3	36	38
GP-C7117105	34	13	13
GP-C1817105	34	13	37
KZN-D	42	43	25	161	31
KZN-F	42	43	25	31	31
KZN-K	27	13	4	4	37
KZN-Y	143	144	145	146
KZN-MM	42	43	25	31
KZN-14	142	43	25	31
KZN-19	141	140	140
KZN-49	147	148	149	150
KZN-51	147
EC-22	27	13	4	4	37
EC-23	151	152	4	4	153
EC-24	27	13	4
WC-4	40	Q	Q	m
WC-6	3	4	4	37
WC-7	M	M	M	M
WC-8	34	4	37
WC-10	154
WC-11	40	Q	Q	Q	Q	37
WC-12	27	13	37
WC-12	M	Q	M	Q	M
WC-14	155	36	38
WC-15	160	13	37	4	161
WC-16	34	13	4	13	13	4	37
Spain
Va-48	40	47	47	32	C	C				[30]
United States
Florida	A	B	B	B	B	B	B	B		[30]
California	B	B	C
Okeechobee, FL	L	B	C	B	C
Illinois	M	N	B	M	H
Idaho	D	D	D	D	D	E
Virginia	A	B
Wetumka, OK	K	C	H
Cushing, OK	L	C	B	C
Cushing 2, OK	K	N	N	F	H
Glencoe 1, OK	K	F	N	F	H
Glencoe 2, OK	B	M	F	H
Glencoe 3, OK	T	B	C
Stillwater, OK	K	F	F	F	H
Stillwater 2, OK	L	B	C	C
Stillwater 68, OK	K	B	M	F	H
Stillwater 483, OK	K	B	M	H
Oklahoma City, OK	U
Okmulgee, OK	K	B	V	C
Stigler, OK	T	B	B	C
Pawhuska, OK	I	H
New Castle, OK	L	B	C	B
St. Maries	J	B	B
Mississippi	D	D	D	D	E
Oregon	G
Oregon, Rasmusen	A	F	H
US bison (buffalo)	K	B	M	F	W
Washington	B	B	B	C
Missouri	B	B	B	B
Texas	O	B	M	P
Texas 198	B	B	m	B	m
South Dakota	A	F	H
Kansas 3261	B	B
Kansas 4102	B	B	B
Kansas 2267	B	B	B	B
Kansas 0141	B	B	B	B	B
Kansas 0063	B	B	B	B	B	B
Kansas 5076	D	D	D	D	D
Kansas 7042	D	D	E
Kansas 4318	D	D	D	D	D	E
Kansas 2070	D	D	D	D	D	D	E
Kansas 7030	D	D	D	D	D	D	D	D	D
Kansas 0050	E	M