Design of Infusion Schemes for Neuroreceptor Imaging: Application to [¹¹C]Flumazenil-PET Steady-State Study

Table 4

Time for the distribution volume attaining steady-state conditions for population-based programmed infusion (PI) and bolus infusion (BI).

	Time (min)
	PI	BI
Occipital cortex	25 ± 12	38 ± 14
Neocortex	20 ± 9	35 ± 11
Hippocampus	34 ± 10	29 ± 9
Cerebellum	27 ± 14	39 ± 10
Thalamus	30 ± 14	42 ± 9
Pallidostriatum	40 ± 14	41 ± 0
Midbrain	27 ± 14	36 ± 6
White matter	45 ± 12	53 ± 9
Pons	44 ± 15	53 ± 9

The mean and standard deviation are reported. The steady state was determined as the time point, when the change of the time-activity curve was within ±5% of the plateau.