Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton Remodeling

Figure 2

Effects of p53 on molecules in mechanosensing pathways. Cells sense ECM stiffness and modulate actin cytoskeleton structures through the integrin signaling pathways. p53 wild-type suppresses cancer progression through downregulation of the molecules in the integrin signaling pathways. Conversely, several p53 mutants exert gain-of-function effects on the upregulation of molecules in the integrin signaling pathways. The molecules indicated by red letters are upregulated by p53 GOF mutants.