A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart

Figure 4

Suppressing Tpr-Met expression at P21 prevents loss of muscular weight at P27. Doxycycline (DOX) was withdrawn from a group of Tpr-Met mice for 21 days in order to activate Tpr-Met signaling; DOX was subsequently restored. The reduction in body weight gain (a) and (b) body weight (BW) was completely rescued when Tpr-Met transgene expression was suppressed by DOX administration (Tpr-Met + DOX) from P21, perfectly overlapping with values from controls for the whole follow-up. (c) When suppressing Tpr-Met expression at P21, the weight of tibialis anterior (TA), soleus (SOL), and gastrocnemius (GSN) muscles was normalized to values overlapping those of controls. ; ; .

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