A New Transgenic Mouse Model of Heart Failure and Cardiac Cachexia Raised by Sustained Activation of Met Tyrosine Kinase in the Heart
Table 2
Enriched KEGG pathways in down- and upregulated genes (fold change > 1.7; ).Only categories significantly associated ( value < 0.05) are considered. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, number of enriched genes, value, enrichment factor, and list of the genes enriched in each pathway are reported.
KEGG pathway
Number of genes
value
Enrichment factor
Gene list
Gene set: downregulated genes
Tight junction
2
8.0
Actn3, Csda
Melanogenesis
3
16.5
Camk2b, Gnas, and Prkaca
Long-term depression
2
14.3
Ryr1, Gnas
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
2
15.0
Cacnb1, Actn3
GnRH signaling pathway
3
17.0
Camk2b, Gnas, and Prkaca
Prostate cancer
2
12.2
Hsp90ab1, E2f2
Gap junction
2
12.2
Gnas, Prkaca
Galactose metabolism
2
42.4
Gaa, Pfkm
Glioma
2
16.1
E2f2, Camk2b
Dilated cardiomyopathy
3
18.4
Cacnb1, Gnas, and Prkaca
Metabolic pathways
9
4.34
Adssl1, St3gal3, Cox10, Gaa, Atp6v0a1, Gamt, Pfkm, Ndufa10, and Idh3a