Zebrafish: A Versatile Animal Model for Fertility Research

Figure 2

Crosstalk between HPG and HPT in zebrafish. Together with GTH-I, T3 elevates the expression of ar and cyp17a1, leading to increased 11-KT production and sensitivity in zebrafish testicular tissues. Meanwhile, T3 alone plays stimulatory role in the proliferation of Sertoli cells and type A undifferentiated spermatogonia. However, concentrations of thyroid hormones were negatively correlated with amount of GTH-I and GTH-II (blue arrow: HPG; pink arrow: HPT).