Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa

<div><i>Effects of glycine, sodium pyruvate, and resveratrol on base excess (a), bicarbonate (</i><svg height="14.0833pt" id="M23" style="vertical-align:-3.2866pt" version="1.1" viewbox="-0.0498162 -10.7967 39.7345 14.0833" width="39.7345pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M828 650H570L564 622C646 614 650 609 634 524L604 366H253L281 524C296 608 308 615 382 622L388 650H132L126 622C211 615 214 609 198 524L121 122C106 42 102 35 23 28L17 0H276L282 28C196 35 191 40 206 122L243 324H597L559 123C544 42 537 35 452 28L446 0H710L716 28C632 35 628 43 643 122L719 524C735 610 741 615 822 622L828 650Z" id="g113-73"></path></g><g transform="matrix(.013,0,0,-0.013,10.662,0)"><path d="M645 631C614 643 545 666 457 666C215 666 23 519 23 283C23 90 158 -16 337 -16C412 -16 489 2 522 10C543 39 590 127 606 167L580 181C519 89 459 18 348 18C201 18 122 136 122 287C122 464 244 632 435 632C544 632 602 595 608 472L639 475C643 526 645 581 645 631Z" id="g113-68"></path></g><g transform="matrix(.013,0,0,-0.013,19.346,0)"><path d="M699 369C699 549 575 666 407 666C186 666 23 488 23 278C23 101 145 -16 312 -16C535 -16 699 153 699 369ZM600 373C600 210 500 19 321 19C186 19 120 129 120 272C120 450 232 631 399 631C541 631 600 522 600 373Z" id="g113-80"></path></g><g transform="matrix(.0091,0,0,-0.0091,28.838,3.132)"><path d="M118 521L137 502C164 537 202 580 258 579C312 579 342 549 342 497C342 419 268 371 151 338L157 312C170 316 193 321 217 321C277 321 331 282 331 202C331 88 264 38 185 38C127 38 90 68 63 96C56 103 51 103 43 97C29 88 19 75 17 64C15 51 21 38 36 23C56 4 96 -12 133 -12C177 -12 251 7 311 49C384 100 419 162 419 223C419 296 373 349 300 369L301 371C336 392 359 409 377 424C403 445 424 473 424 514C424 577 380 635 295 635C241 635 198 612 166 583L118 521Z" id="g189-232"></path></g><g transform="matrix(.0091,0,0,-0.0091,33.556,-5.741)"><path d="M556 236V289H56V236H556Z" id="g54-33"></path></g></svg><i>; (b)), and arterial lactate concentration (c) after mesenteric ischemia-reperfusion (I/R)</i>. Rats were subjected to mesenteric I/R for 60 min, followed by 300 min of reperfusion. Glycine (15 mg/kg BW × h), sodium pyruvate (50 mg/kg BW × h), and resveratrol (40 <i>µ</i>g/kg BW × h) were administered intravenously 30 min after the ischemic period until the end of the observation period. Control animals (±I/R) received the same volume of 0.9% NaCl solution. Parameters were determined at the end of the reperfusion period. Values are means ± standard deviation (SD). <svg height="13.9365pt" id="M24" style="vertical-align:-3.834pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 13.9365" width="50.9184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 148 486 158Z" id="g50-43"></path></g><g transform="matrix(.013,0,0,-0.013,6.079,.966)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z" id="g113-81"></path></g><g transform="matrix(.013,0,0,-0.013,17.762,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z" id="g117-91"></path></g><g transform="matrix(.013,0,0,-0.013,29.025,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path></g><g transform="matrix(.013,0,0,-0.013,35.265,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z" id="g113-47"></path></g><g transform="matrix(.013,0,0,-0.013,38.229,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z" id="g113-49"></path></g><g transform="matrix(.013,0,0,-0.013,44.469,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z" id="g113-54"></path></g></svg> (versus I/R control). Gly: glycine; Pyr: pyruvate; Res: resveratrol; I/R: ischemia/reperfusion.</div>

BioMed Research International

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Figure 4

Figure 4: Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa 