Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa

Figure 5

Effects of glycine, sodium pyruvate, and resveratrol on the macroscopic score (a) and histopathologic (b) score of the rat small intestine after mesenteric ischemia-reperfusion (I/R). Rats were subjected to mesenteric I/R for 60 min, followed by 300 min of reperfusion. Glycine (15 mg/kg BW × h), sodium pyruvate (50 mg/kg BW × h), and resveratrol (40 µg/kg BW × h) were administered intravenously 30 min after the ischemic period until the end of the observation period. Control animals (±I/R) received the same volume of 0.9% NaCl solution. Parameters were determined at the end of the reperfusion period. Values are means ± standard deviation (SD). (versus I/R control). Gly: glycine; Pyr: pyruvate; Res: resveratrol; I/R: ischemia/reperfusion. is the calculated difference represented in units of standard error.

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(b)