Effect of Glycine, Pyruvate, and Resveratrol on the Regeneration Process of Postischemic Intestinal Mucosa

Table 2

Effects of glycine, sodium pyruvate, and resveratrol on plasma electrolyte concentrations, hematocrit, and pH.

Parameter	^1Na^+ [mmol/L]	^2K^+ [mmol/L]	^3Ca^2+ [mmol/L]	^4Cl^− [mmol/L]	Hematocrit [%]	pH
Sham	140 ± 1.3	5.2 ± 0.5	1.5 ± 0.1	119 ± 2.4	36.1 ± 2.	7.2 ± 0.1
Ischemia-reperfusion	141 ± 2.8	5.5 ± 0.5	1.4 ± 0.1	125 ± 4.4	41.7 ± 3.6	7.2 ± 0.1
Glycine + I/R	141 ± 1.9	5.6 ± 0.4	1.4 ± 0.1	125 ± 4.4	37.9 ± 7.1	7.1 ± 0.3
Pyruvate + I/R	141 ± 2.6	5.2 ± 0.5	1.4 ± 0.1	121 ± 4.2	40.2 ± 3.5	7.3 ± 0.1
Resveratrol + I/R	141 ± 3.2	5.6 ± 0.4	1.4 ± 0.1	128 ± 5.4	41.7 ± 6.7	7.2 ± 0.1

Rats were subjected to mesenteric I/R for 60 min, followed by 300 min of reperfusion. Glycine (15 mg/kg BW × h), sodium pyruvate (50 mg/kg BW × h), or resveratrol (40 µg/kg BW × h) were administered intravenously 30 min after the onset of reperfusion until the end of the observation period. Control animals (±I/R) received the same volume of 0.9% NaCl solution. Parameters were determined at the end of the reperfusion period. Values are means ± standard deviation (SD). (versus I/R control).