Citalopram Ameliorates Impairments in Spatial Memory and Synaptic Plasticity in Female 3xTgAD Mice

Figure 3

Citalopram treatment ameliorated the impairments in spatial learning and memory of 3xTgAD mice in Morris water maze test. (a) Plots showing the changes in the escape latencies of mice in different groups over the 5-day training period. The escape latency of 3xTgAD mice was longer than that of WT mice on the fifth day, and citalopram reversed it. (b) The number of platform crossings was decreased in 3xTgAD mice, which was reversed by citalopram. (c) Representative swimming traces of mice in the probe test. Error bars indicate SEM. , .

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