Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic Injury

Figure 3

Histological analysis of brain regions (cortex and hippocampus) showed significant injury after HI. Hypothermia treatment (HT) or PARP inhibition (TES448) alone leads not to significant brain protection but a combined treatment (HT + TES448) reduced injury scoring in the hippocampus of male pups to the level of sham animals (a). In contrast, females were less severely injured after HI in the hippocampus but a combined treatment using hypothermia and TES448 augmented brain injury although no significant difference was detected (b). Values are presented as box plots including median values, the 25% and the 75% percentile, , one-way ANOVA with Bonferroni’s multiple-comparison test, males = 5–19 per group, and females = 10–19 per group.

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