Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic Injury

Figure 5

Protein expression of NeuN (a), Olig2 (b), MBP (c), and Iba-1 (d) was analyzed in protein lysates using the entire hemisphere of animals exposed to HI followed by TES448 treatment. Hypoxic-ischemic injury triggered a decrease of NeuN and Olig2 but additional TES448 therapy had no impact on protein expression. MBP expression was not affected by HI or PARP inhibition. Iba-1 expression was increased in hypoxic-ischemic animals injected with NaCl compared to sham control pups. Animals receiving TES448 treatment after HI reached the level of sham animals (d). Results are expressed as box plots including median values, the 25% and the 75% percentile, , , one-way ANOVA with Bonferroni’s multiple-comparison test, and = 8–11 per group).

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