Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis

Figure 2

Phosphorylated HDAC4 contributes to angiogenesis in vivo. ((a) and (b)) MCAO rats were injected with GÖ6976 or vehicle control for 48 hours (/group). Expression change of P-HDAC4 in the ischemic penumbra cortex and contralateral cortex was measured by Western blot analysis. Quantitative analysis is shown in (b). ((c), (d), and (e)) Microvessel density was assessed 48 hours after injection of GÖ6976 or vehicle control. Representative images are shown in (c) and the number of microvessels is quantified in (d) and (e). Data are presented as mean ± SD. NS, nonstatistically significant. versus L; versus 48 h+G. Scale bar = 50 μm.

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