Computational Identification and Characterization of a Promiscuous T-Cell Epitope on the Extracellular Protein 85B of Mycobacterium spp. for Peptide-Based Subunit Vaccine Design
Table 4
Binding of 181-QQFIYAGSLSALLDP-195 epitope of Ag85B to respective allele predicted by NetMHCII 2.2 servers.
MHC II alleles
Promiscuous peptide sequence
Affinity (nM)
Full peptide (15 mer)
Core peptide (9 mer)
HLA-DRB10101
QQFIYAGSLSALLDP
FIYAGSLSA
4.5
HLA-DRB10404
QQFIYAGSLSALLDP
FIYAGSLSA
49.1
HLA-DRB10405
QQFIYAGSLSALLDP
FIYAGSLSA
20.7
HLA-DRB10701
QQFIYAGSLSALLDP
FIYAGSLSA
6.1
HLA-DRB10901
QQFIYAGSLSALLDP
FIYAGSLSA
9.2
HLA-DRB50101
QQFIYAGSLSALLDP
FIYAGSLSA
33.7
HLA-DPA10201-DPB10101
QQFIYAGSLSALLDP
FIYAGSLSA
38.1
HLA-DQA10501-DQB10301
QQFIYAGSLSALLDP
FIYAGSLSA
5.7
Binding affinity below 50 nM is considered as strong immunogenicity.