Synthesis of L-Ascorbyl Flurbiprofenate by Lipase-Catalyzed Esterification and Transesterification Reactions

Table 1

The effect of solvent on the conversion of esterification and transesterification.

Solvent		Conversion of L-ascorbic acid (%)
		Esterification	Transesterification
Acetone	−0.23	4.6	30.0
Tert-butanol(2-methyl-2-propanol)	0.60	36.0	38.5
Ethyl acetate	0.68	11.1	9.8
Tert-amyl alcohol; 2-methyl-butanol	0.89	35.3	36.5
Benzene	2.00	—	—
Chloroform	2.00	3.5	—
Toluene	2.50	—	—