Research Article
MicroRNA-Related Polymorphisms in PI3K/Akt/mTOR Pathway Genes Are Predictive of Limited-Disease Small Cell Lung Cancer Treatment Outcomes
Table 1
Clinical characteristics of 146 patients with limited disease-small cell lung cancer.
| Variables | (%) | 5yOS | |
| Gender | | | | Male | 104 (71.2%) | 33.0% | 0.065 | Female | 42 (28.8%) | 47.2% | Age | | | | ≤60 | 95 (65.1%) | 43.0% | 0.015 | >60 | 51 (34.9%) | 30.8% | KPS | | | | ≥90 | 61 (41.8%) | 47.5% | 0.009 | <90 | 85 (58.2%) | 33.1% | Location | | | | Left lobe | 69 (47.3%) | 39.3% | 0.987 | Right lobe | 77 (52.7%) | 37.8% | Smoking | | | | Yes | 96 (65.8%) | 35.7% | 0.088 | No | 50 (34.2%) | 40.1% | Charlson comorbidity index | | | | ≤3 | 130 (89.0%) | 41.7% | 0.030 | 4-5 | 13 (8.9%) | 19.5% | 6-7 | 3 (2.1%) | 0% | Weight loss | | | | With | 27 (18.5%) | 51.3% | 0.393 | Without | 119 (81.5%) | 35.2% | AJCC stage | | | | IA | 1 (0.7%) | 100.0% | 0.573 | IB | 2 (1.4%) | 0% | IIA | 5 (3.4%) | NA | IIB | 4 (2.7%) | NA | IIIA | 68 (46.6%) | 41.7% | IIIB | 66 (45.2%) | 34.9% | Treatment modality | | | | Concurrent | 80 (54.8%) | 46.8% | 0.401 | Sequential | 66 (45.2%) | 31.2% | Chemotherapy cycles | | | | <4 | 9 (6.2%) | NA | 0.382 | 4–6 | 126 (86.3%) | 40.2% | >6 | 11 (7.5%) | 38.6% | Radiotherapy dose | | | | <60 | 46 (30.7%) | 39.3% | 0.525 | ≥60 | 100 (69.3%) | 39.9% | PCI | | | | With | 63 (43.2%) | 62.1% | | Without | 83 (56.8%) | 23.1% |
|
|
OS: overall survival; AJCC: American Joint Committee on Cancer; PCI: prophylactic cranial irradiation.
|