Profiling microRNA from Brain by Microarray in a Transgenic Mouse Model of Alzheimer’s Disease

Table 1

Changes in expression of miRNAs in 1-month-old, 3-month-old, 6-month-old, and 9-month-old APP/PS1 mice as compared to age-matched WT controls.

	Change	miRNA ID	miRNA name	Fold change	value
1-month-old APP/PS1 mice versus WT control	Up	30681	mmu-miR-376c-3p	2.023	0.048
		42576	mmu-miR-342-5p	2.636	0.012
		42646	mmu-miR-878-3p	8.470	0.027
		32884	mmu-miR-342-3p	3.266	0.029
	Down	146015	mmu-miR-1940	0.446	0.005
		168826	mmu-miR-5624-5p	0.500	0.010
		145692	mmu-miR-499-3p	0.420	0.047
		148259	mmu-miR-3070a-5p/mmu-miR-3070b-5p	0.497	0.008
3-month-old APP/PS1 mice versus WT control	Up	148453	mmu-miR-3074-5p	2.731	0.03
		17835	mmu-miR-450a-5p	2.621	0.011
		146004	mmu-miR-2136	2.146	0.023
		148047	mmu-miR-3058-3p	2.761	0.027
		42576	mmu-miR-342-5p	2.066	0.049
		169158	mmu-miR-344i	2.163	0.049
		17752	mmu-let-7f-5p	2.297	0.020
		46728	mmu-miR-3059-3p	3.315	0.043
		145836	mmu-miR-218-2-3p	2.910	0.036
		148074	mmu-miR-539-3p	3.002	0.019
		169301	mmu-miR-3967	2.224	0.043
	Down	145705	mmu-miR-431-5p	0.405	0.021
		42595	mmu-miR-291a-3p	0.493	0.021
		147701	mmu-miR-491-3p	0.381	0.034
6-month-old APP/PS1 mice versus WT control	Up	146199	mmu-miR-1961	2.696	0.034
		13485	mmu-miR-10a-5p	2.841	0.002
		17835	mmu-miR-450a-5p	2.483	0.006
		42712	mmu-miR-742-5p	2.692	0.009
		146004	mmu-miR-2136	2.057	0.004
		42664	mmu-miR-301b-3p	2.668	0.023
		14189	mmu-miR-302b-5p	3.141	0.043
		145633	mmu-let-7d-3p	2.088	0.033
		19601	mmu-miR-211-5p	2.769	0.019
		11182	mmu-miR-98-5p	2.099	0.017
		32884	mmu-miR-342-3p	2.476	0.005
		27571	mmu-miR-292-5p	2.104	0.026
		46275	mmu-miR-1251-5p	2.329	0.002
		148017	mmu-miR-743a-5p	2.538	0.034
		10916	mmu-miR-1a-3p	2.140	0.017
		146137	mmu-miR-133a-3p	2.868	0.022
		148423	mmu-miR-652-5p	2.230	0.027
		17752	mmu-let-7f-5p	2.782	0.010
		11210	mmu-miR-215-5p	2.589	0.040
		146160	mmu-miR-133b-3p	2.285	0.044
		168586	mmu-miR-34a-5p	2.416	0.027
		42587	mmu-miR-881-5p	2.104	0.006
		46859	mmu-miR-135a-2-3p	2.192	0.044
		145914	mmu-miR-135b-5p	2.186	0.006
	Down	42767	mmu-miR-34c-3p	0.412	0.009
		145705	mmu-miR-431-5p	0.326	0.017
		145637	mmu-miR-187-3p	0.294	0.024
		42929	mmu-miR-25-5p	0.374	0.049
		148276	mmu-miR-3073a-3p	0.322	0.017
		147701	mmu-miR-491-3p	0.422	0.046
9-month-old APP/PS1 mice versus WT control	Up	30681	mmu-miR-376c-3p	2.407	0.015
		42494	mmu-miR-712-3p	2.721	0.033
		32884	mmu-miR-342-3p	4.074	0.0001
		169373	mmu-miR-5626-5p	2.195	0.009
		46297	mmu-miR-3085-3p	2.229	0.002
	Down	148605	mmu-miR-128-2-5p	0.430	0.030
		42595	mmu-miR-291a-3p	0.256	0.019
		148105	mmu-miR-3106-3p	0.359	0.034
		17866	mmu-miR-331-5p	0.403	0.020
		42625	mmu-miR-299a-3p	0.371	0.033
		148525	mmu-miR-1964-5p	0.241	0.039
		145757	mmu-miR-33-3p	0.487	0.002
		42621	mmu-miR-879-3p	0.401	0.031
		11038	mmu-miR-299a-5p/mmu-miR-299b-5p	0.310	0.002