Research Article

Orthostatic Intolerance and Postural Orthostatic Tachycardia Syndrome in Joint Hypermobility Syndrome/Ehlers-Danlos Syndrome, Hypermobility Type: Neurovegetative Dysregulation or Autonomic Failure?

Table 3

Valsalva maneuver: comparison of JHS/EDS-HT patients stratified according to the heart rate response to tilting (#21).

POTS (10/35) Non-POTS (11/35)
VariablemmHg ± dsVariablemmHg ± ds

Baseline SBP/DBP117/74.5 ± 11.6/6.8Baseline SBP/DBP111/70 ± 9.2/8 = 0.23
Maximal drop of SBP during early phase II24.5 ± 10.6Maximal drop of SBP during early phase II21.9 ± 24.3 = 0.7
maximal drop of DBP during early phase II3.9 ± 9.1Maximal drop of DBP during early phase II3.6 ± 16 = 0.7
SBP at late phase II125 ± 13.1SBP at late phase II118 ± 18 = 0.48
DBP at late phase II89.5 ± 11.6DBP at late phase II84 ± 17 = 0.4
SBP at late phase IV142.5 ± 19.6SBP at late phase IV132 ± 22.4 = 0.27
DBP at late phase IV87 ± 15.6DBP at late phase IV78.6 ± 15.1 = 0.22
Difference between late phase II SBP and early phase II SBP31.8 ± 17.9Difference between late phase II SBP and early phase II SBP30.8 ± 9.2 = 0.6
Difference between late phase II DBP and early phase II DBP18.9 ± 9Difference between late phase II DBP and early phase II DBP18. 8 ± 6.3 = 0.7

Normal values: Maximal drop of mean blood pressure (MBP) during early phase II: ≥20 mmHg; systolic blood pressure (SBP) and diastolic blood pressure (DBP) at late phase II: ≥baseline; SBP and DBP at late phase IV: ≥baseline.