Association between NLPR1, NLPR3, and P2X7R Gene Polymorphisms with Partial Seizures
Table 2
Genotypic and allelic distribution of the NLRP1 gene between all patients and controls .
SNP
Genotype/allele
Case (%)
Control (%)
value
OR (95% CI)
value
rs8079034
CC
120 (73.6)
153 (76.1)
0.752 (0.569)
1.00
Referent
CT
37 (22.7)
43 (21.4)
0.911 (0.553–1.503)
0.717
TT
6 (3.7)
5 (2.5)
0.654 (0.195–2.193)
0.491
CT + TT
43 (26.4)
48 (23.9)
0.584 (0.300)
0.876 (0.544–1.409)
0.584
C
277 (85.0)
349 (86.8)
0.475 (0.509)
1.00
Referent
T
49 (15.0)
53 (13.2)
0.858 (0.565–1.306)
0.476
rs878329
GG
123 (75.5)
121 (60.2)
0.009 (9.486)
1.00
Referent
GC
35 (21.5)
70 (34.8)
2.033 (1.262–3.276)
0.004
CC
5 (3.0)
10 (5.0)
2.033 (0.675–6.123)
0.207
GC + CC
40 (24.5)
80 (39.8)
0.002 (9.486)
2.033 (1.290–3.204)
0.002
G
281 (86.2)
312 (77.6)
0.003 (8.782)
1.00
Referent
C
45 (13.8)
90 (22.4)
1.801 (1.217–2.667)
0.003
CI, confidence interval; OR, odds ratio. value for genotype and allele frequencies in cases and controls using 2-sided test. values adjusted by age and gender using logistic regression. .
