Donation after Circulatory Death in Paediatric Liver Transplantation: Current Status and Future Perspectives in the Machine Perfusion Era

Table 1

Donation after circulatory death in paediatric liver transplantation.

Author

Number of recipients

Recipient age

Recipient gender (M/F)

Type of graft

Donor age (years)

Donor cause of death

ITU donor stay (days)

Donor WIT (minutes)

CIT (hours)

UK DCD; Risk-

Follow-up

Patient status

Complications

Muiesan et al. 2006 [17]; Bartlett et al. 2010 [18]

14

7 yr (8 mo–16 yr)

7 M/0 F

4: whole graft; 8: reduced graft; 1: split LLS; 1: auxiliary LT

23 (10–64)

-7 Anoxia; -4 Trauma; -3 CVA

5 (2–4)

16 (11–29)

7 (5.5–8.4)

2

41.8 (1.7–74) months

All alive

2: pleural effusion; 1: sepsis; 4: early ACR; 2: ductopenic rejection

Abt et al. 2006 [19]

19

yr

12 M/7 F

Whole liver

12.2 ± 14.4

-10 Trauma; -7 Anoxia; -1 CVA; -1 Others

NA

2

60 months

NA

2: (10.5%) retransplantation; 1: (5.3%) PNF

Perera et al. 2009 [20]

2

6 weeks; 7 yr

0 M/2 F

Reduced graft

14; 20

-1 Trauma; -1 Meningitis

NA

22; 25

8 h 29 min; 9 h 34 min

5

6 months; 3 years

All alive

1: early ACR; 1: ischemic cholangiopathy

Gozzini et al. 2010 [21]

4

9.5 (0.2–17) yr

1 M/3 F

2: reduced graft; 2: whole graft

14.2 (11–20)

-2 Trauma; -1 Anoxia; -1 Meningitis

2.5 (1–5)

12 (10–15)

7 (6–8)

2

19 (8.1–43.4) months

All alive

2: early ACR; 2: ischemic cholangiopathy

Gelas et al. 2012 [22]

1

2 weeks

1 M/0 F

ABO-incompatible reduced graft

NA

Anoxia

4

15

6

2

13 months

All Alive

Early ACR; chronic rejection

Hong et al. 2014 [23]

7

28.4 (9.6–59.2) mo

3 M/4 F

Whole graft

2.4 (0.3–6)

NA

<5

24

5 (4–7)

3

10 years

All Alive

1: anastomotic biliary stricture

van Rijn et al. 2017 [24]

3

8.6 (6–13) yr

NA

Whole liver

5 (3–9)

NA

NA

25 (20–31)

8 (7–9)

5

10 years

1 Dead; 2 Alive

2: hepatic artery thrombosis; 1: portal vein thrombosis

ACR, acute cellular rejection; F, female; LLS, left lateral segment; LT, liver transplantation; M, male; mo, months; NA, not available; PNF, primary nonfunction; yr, years. -DCD Risk Score was calculated without body mass index and Paediatric End-Stage Liver Disease score values due to lack of data available.