Bioinformatical Analysis of Organ-Related (Heart, Brain, Liver, and Kidney) and Serum Proteomic Data to Identify Protein Regulation Patterns and Potential Sepsis Biomarkers

Figure 1

Network analysis of serum proteins. In a GeneMania network analysis, each circle represents a gene. The input proteins/genes are depicted as striped circles of the same size, while the monochromatic circles, whose size is proportional to the number of interactions according to the software, can be considered “relevant” related genes found by GeneMania searching in many large, publicly available biological datasets (including protein-protein, protein-DNA, and genetic interactions, pathways, reactions, gene and protein expression data, protein domains, and phenotypic screening profiles). Lines linking different circles can be distinguished from their colour; mainly violet represents coexpression (when expression levels are similar across conditions in a gene expression study); light orange represents predicted functional relationships between genes.