Propofol Reversed Hypoxia-Induced Docetaxel Resistance in Prostate Cancer Cells by Preventing Epithelial–Mesenchymal Transition by Inhibiting Hypoxia-Inducible Factor 1α

Figure 2

Propofol reversed hypoxia-induced docetaxel resistance in prostate cancer cells. (a–c) Human prostate cancer cells were treated with propofol for 48 h, and cell viability was measured using CCK-8. versus 0 μM. (d–f) Cell viability was measured in prostate cancer cells treated with docetaxel with or without propofol (40 μM) under hypoxic conditions for 48 h. (g–i) EdU assay detection of the proliferation rate of prostate cancer cells treated with docetaxel or docetaxel plus propofol under hypoxic conditions. Histograms represent the positive cell rate (%). versus hypoxia + docetaxel. DTX, docetaxel. (j) Western blotting detection of HIF-1α expression following propofol treatment under hypoxic or normoxic conditions.