The Polymorphism in ADORA3 Decreases Transcriptional Activity and Influences the Chronic Heart Failure Risk in the Chinese
Table 1
Demographic and clinical characteristics of populations.
Xi’an population
Kunming populations
Chronic heart failure
Controls
value
Chronic heart failure
Controls
value
Age (years)
61.41 ± 12.51
60.33 ± 8.56
0.2
59.78 ± 7.38
59.34 ± 7.46
0.429
Males/females
175/125
211/189
0.14
136/168
158/244
0.15
Hypertension
172 (57.33%)
122 (30.5%)
<0.001
170 (55.92%)
122 (30.35%)
<0.001
Dyslipidemia
84 (28%)
81 (20.25%)
0.0168
70 (23.03%)
85 (21.14%)
0.55
Diabetes
104 (34.67%)
67 (16.75%)
<0.001
101 (33.22%)
67 (16.67%)
<0.001
Smoking habit
91 (30.33%)
62 (15.5%)
<0.001
91 (29.93%)
63 (15.67%)
<0.001
CAD
180 (60%)
—
200 (65.79%)
—
ICDM
76 (25.33%)
—
90 (29.61%)
—
HC
9 (3%)
—
6 (1.97%)
—
Other diagnose
35 (11.67%)
—
8 (2.63%)
—
LVEF ≤ 40%
207 (69%)
—
202 (66.45%)
—
NYHA class:
II
94 (31.33%)
—
101 (33.22%)
—
III
117 (39%)
—
118 (38.82%)
—
IV
89 (29.67%)
—
85 (27.96%)
—
CAD: coronary artery disease; ICDM: idiopathic dilated cardiomyopathy; HC: hypertensive cardiomyopathy; LVEF: left ventricular ejection fraction; NYHA: New York Heart Association class; values were calculated by separate variance estimation -test as variance between the two group is not neat; values were calculated from two-sided -test.
